The purpose of this course is to explore the subject of human disease, placing special emphasis on the cause of disease at the tissue level. We will pay close attention to the underlying mechanisms that initiate and perpetuate the disease state. Much can be learned about the causes of disease at the molecular and cellular level; we will accordingly spend quite a bit of time examining molecules, cells, and tissues and determining how the disruption of their normal functioning by various known and unknown causes can lead to disease. We will begin this course with a basic review of molecules, cells, and tissues in the human body. We will then discuss the bodys first line of defense, the inflammatory reaction, and the immune system. Finally, we will survey the bodys organ systems. We will approach each of the systems by examining the ways in which a prototype disease impacts its functioning. (These "prototypes" will be diseases that impact a large number of patients around the world.) We will conclude by discussing what can be learned about a disease and the cause of death using an autopsy examination.
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