There are a number of bottlenecks preventing interesting applications from being ported (say, from server-heavy implementations) to client-side JavaScript. Some of these include browser compatibility, static typing, accessibility, and performance. Fortunately, the latter is quickly becoming a thing of the past as browser vendors rapidly improve the speed of their JavaScript engines. One thing that's remained a hindrance for JavaScript is actually the language itself. JavaScript is a single-threaded environment, meaning multiple scripts cannot run at the same time. As an example, imagine a site that needs to handle UI events, query and process large amounts of API data, and manipulate the DOM. Pretty common, right? Unfortunately all of that can't be simultaneous due to limitations in browsers' JavaScript runtime. Script execution happens within a single thread.
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